Effect of curcumine on fractalkine of lung tissue in pulmonary thromboembolism rats

Objective To investigate the changes of fractalkine(FKN)of lung tissues in pulmonary thromboembolism(PTE) and intervention function of curcumin(Cur).Methods PTE model was established by autologous blood clot.A total of 96 rats were randomly divided into six groups:control group,sham group,model group,Cur-low group,Cur-medium group,and Cur-high group,16 in each.Pathological changes of the lungs were observed by hematoxylin-eosin(HE) staining.The lung coefficient and mRNA levels of FKN,tumor necrosis factor alpha(TNF-α),interleukin 1β(IL-1β) in blood and lung tissue were detected at 4 and 72 h after embolism.Results There was no significant difference between each group on the lung coefficient after embolism at 4 and 72 h(all P 0.05).The blood serum FKN level in the control group was obviously lower than the model group at 4 h after embolism,while at 72 h,the control,sham,Cur-high groups were all lower than the model group(all P 0.01).The mRNA levels of FKN,TNF-α,IL-1β in the lung tissue were significantly lower in the control,sham,Cur-low,Cur-medium,Cur-high groups as compared with the model group at 4 and 72 h after embolism(all P 0.01).HE staining assumed that the pulmonary alveolar capillaries remarkably expanded and revealed hyperemia at 72 h after embolism.Hemorrhagic infarction could be seen in several rats under the light microscope.After the rats applied with Cur,the lung congestion released.Conclusion Cur could decrease the FKN levels in the rats with PTE.