Ropinirole Delays Risk for Levodopa-Induced Dyskinesia in PD

This 5-year, prospective, double-blind, randomized, multicenter, manufacturer-supported trial compared the efficacy and safety of ropinirole, a dopamine agonist, with levodopa as initial therapy in 268 patients with early Parkinson's disease (PD). Patients in both groups could receive supplemental, open-label levodopa if necessary; of 85 patients in the ropinirole group who completed the study, 29 …