Normal tolerance limits for side-to-side differences in diameters of major lower limbs arteries of 228 healthy subjects.

Abstract Purpose To determine reference values and tolerance limits of between-side differences for the calibers of the common femoral artery (CFA), superficial femoral artery (SFA), popliteal artery (PA), dorsalis pedis artery (DPA), and posterior tibial artery (PTA). Materials and methods Calibers of arteries, defined as the largest distance between internal hyperechogenic lines of the intima-media complex of the arterial wall, were measured during the diastole phase determined from echo-tracking B mode ultrasound scanning and grey-scale ultrasound in 228 healthy volunteers aged 18–81 years (43.1 ± 16.7). Results The mean, 95% confidence and tolerance limits covering 90% of population for left and right side of each artery were: CFA: 8.1 mm, 7.9–8.3 mm, 6.0–10.3 mm; 8.1 mm, 7.9–8.5 mm, 5.9–10.2 mm; SFA: 6.2 mm, 6.0–6.3 mm, 4.7–7.6 mm; 6.1 mm, 6.0–6.3 mm, 4.7–7.6 mm; PA: 6.1 mm, 6.0–6.2 mm, 4.6–7.6 mm; 6.1 mm, 5.9–6.2 mm, 4.5–7.6 mm; DPA: 2.0 mm, 1.9–2.0 mm, 1.2–2.7 mm; 2.0 mm, 1.9–2.0 mm, 1.2–2.8 mm; PTA: 2.1 mm, 2.0–2.1 mm, 1.4–2.8 mm; 2.1 mm, 2.1–2.2 mm, 1.4–2.8 mm, respectively. Tolerance limits for between-side differences and ratios were: CFA - 0.5–0.7 mm, 0.9–1.1; SFA - 0.5–0.6 mm, 0.9–1.1; PA - 0.5–0.5 mm, 0.9–1.1; DPA -0.4-0.4 mm, 0.8–1.2; PTA - 0.4–0.4 mm, 0.8–1.2. Regression analysis showed weight and age dependency of vessels diameters. There are no differences between men and woman in vessels size, except in DPA's, when body weight and age are taken into account in a regression analysis. Conclusions We estimated normal reference tolerance limits of side-to-side differences in diameters of lower limb arteries. The limits can inform an investigator what differences in diameters occur in healthy individuals, and hence can serve as cut-offs in diagnostic and screening strategies.