Clinicopathological spectrum of solitaryPlasmacytoma: a single center experiencefrom coastal India

Background:Plasma cell disorders are a rare group of hematological malignancies that accounts for 10% of allhematological neoplasms. Solitary plasmacytomas are rarer entities accounting for less than 5% of all the plasmacell dyscrasias. They encompass three subtypes - Solitary Plasmacytoma of Bone (SPB) and Solitary ExtramedullaryPlasmacytoma (SEP) and multiple solitary plasmacytomas (MSP). In this study, we discuss the clinical,histopathological and immunohistochemical characteristics of solitary plasmacytomas.Methods:A 13 year retrospective analysis of solitary plasmacytomas was performed from a single tertiary carecenter. Bone marrow evaluation was done concurrently at the time of diagnosis to rule out the presence ofmultiple myeloma.Results:A total of 29 cases fulfilled the diagnostic criteria for SP during the study period. SPB accounted for 55.2%,SEP for 44.4% and MSP for 3.4% of the cases. The most common sites involved were the paranasal sinuses andvertebrae. Other infrequent sites included lymph node, tonsil and lungs. The meanage of presentation of SPBwas a decade later than SEP. A male preponderance was observed in both subtypes.Conclusion:Solitary plasmacytoma is a rare entity, the diagnosis of which requires a systematic approach.There is limited data available in the literature on the clinico-pathological characteristics of SP from India