Randomized clinical trial on a hydrating intimate cleanser as an adjuvant in vulvar dermatosis therapy

Abstract Objective Vulvar dermatoses are characterized by dehydration leading to symptoms as itching and burning. Topical corticosteroids and lanolin cream are the standard therapy. A new non-irritant cleanser based on soft natural surfactants (Saugella idraSerum, a product by Rottapharm|Madaus) (SiS) exhibited interesting clinical properties. Purpose of the study was to compare the activity of SiS in vulvar dermatoses versus a common reference cleanser (Aveeno intimo) (Ref). Methods In a controlled randomized clinical study 32 patients with vulvar dermatosis received Mometasone 2 applications weekly and lanolin cream 1 application daily for 7 days followed by 1 application as needed. To one half of the patients SiS and to half of patients Ref were recommended as daily cleanser bid for 1 month. Any onset of symptoms was checked before and after treatment. Results Burning improved after SiS treatment vs Ref in a significantly higher rate (respectively 80% vs 25%, P vs 50.0%, P =0.10) though the Ref group applied a significantly higher number of doses of emollient cream as needed. Conclusion This new-generation intimate cleanser was effective in reducing burning and the concomitant emollient treatment in vulvar dermatoses.