Process Variables and Design of Experiments in Liposome and Nanoliposome Research.
2018
Liposomes vesicles consisting of one or more phospholipid bilayers
are microcarriers used in numerous scientific disciplines. During the last
decade, nanostructured liposomes, or nanoliposomes, have been utilized in
biomedical investigations due to their unique characteristics including
nanoscale size, sustained release, biocompatibility, and biodegradability.
The extensive literature covering the field of liposomology is an indication
of increasing interests and applications in many areas, especially as
carriers of active substances in nanomedicine, agriculture, food technology,
and cosmetics. Nanoliposomes application as drug carriers resulted in more
effective treatment of such diseases as cancers, atherosclerosis, infectious
diseases and ocular disorders. In this communication we will introduce
commonly used methods in liposomal preparation, identify the research and
therapeutic field that utilize liposomes, and discuss the common process
variables in liposome encapsulations. We will also review different
screening methods and full and fractional factorial designs that impact
independent variables in certain applications and the end-user response. We
will review such key factors as encapsulation efficiency, loading capacity,
particles’ biologics, structural and physicochemical properties, and lipid
composition in an effort to provide a comprehensive guide for
liposomologists in different field of interest.
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