Respiratory syncytial virus receptor expression in the mouse and viral tropism
2015
Human respiratory syncytial virus (RSV)
infects airway epithelium and can cause serious illnesses
such as bronchiolitis and pneumonia. With the discovery
of cell-surface nucleolin as a fusion receptor for RSV,
the question arose as to whether nucleolin could explain
RSV tropism in vivo. Here, we report the distribution of
cell-surface nucleolin expression in tissues of normal
mice and how this distribution of expression relates to
what is known about RSV tropism and its clinical
manifestations. Our results show evidence of cellsurface
nucleolin expression in the respiratory tract. In
addition, cell-surface nucleolin is expressed in tissues
outside of the respiratory tract, many of which
correspond to previous reports of tissue-specific RSV
infection, and others that may allude to additional
potential sites for RSV infection in vivo. Furthermore,
our work provides a foundation for the investigation of
nucleolin’s physiological function in various healthy
mammalian tissues.
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