The effect of PVP application on Mebendazole release from electrospun nanofibers, kinetic study and thermodynamic analysis

Hydatid cyst is a common disease between humans and canines. Mebendazole has been used to treat this disease. Understanding and upgrading Mebendazole drug delivery system are the aim of this study. In this study, nanofibers containing drugs were fabricated by electrospinning. In the structure of nanofibers, polyvinylpyrrolidone (PVP) polymer is used as a drug release controller. In vitro, the living protoscoleces were exposed to nanofibers and the controlling effect of PVP was monitored using live protoscoleces mortality observation. The study found that PVP could be an effective controller of Mebendazole release from nanofiber. The higher the amount of PVP in the nanofibers, the lower the drug release rate and consequently the protoscoleces mortality rate decreases. Based on the statistical results of mortality, protoscoleces showed that PVP had significant controlling effects (p   0) are positive and that the process is endothermic. Entropy changes (ΔS   0) indicate that drug release from the nanofibers is not spontaneous. Nanofibers that have more controller have a larger activation energy (Ea).