Sex differences in the prevalence and prognostic impact of physical frailty and sarcopenia among older patients with heart failure

Abstract Background and Aims Frailty and sarcopenia are common and confer poor prognosis in elderly patients with heart failure; however, gender differences in its prevalence or prognostic impact remain unclear. Methods and Results We included 1,332 patients aged ≥65 years, who were hospitalized for heart failure. Frailty and sarcopenia were defined using the Fried phenotype model and Asian Working Group for Sarcopenia criteria, respectively. Gender differences in frailty and sarcopenia, and interactions between sex and prognostic impact of frailty/sarcopenia on 1-year mortality were evaluated. Overall, 53.9% men and 61.0% women and 23.7% men and 14.0% women had frailty and sarcopenia, respectively. Although sarcopenia was more prevalent in men, no gender differences existed in frailty after adjusting for age. On Kaplan-Meier analysis, frailty and sarcopenia were significantly associated with 1-year mortality in both sexes. On Cox proportional hazard analysis, frailty was associated with 1-year mortality only in men, after adjusting for confounding factors (hazard ratio [HR], 1.94; 95% confidence interval [CI], 1.19–3.16; P=0.008 for men; HR, 1.63; 95% CI, 0.84–3.13; P=0.147 for women); sarcopenia was an independent prognostic factor in both sexes (HR, 1.93; 95% CI, 1.13–3.31; P=0.017 for men; HR, 3.18; 95% CI, 1.59–5.64; P=0.001 for women). There were no interactions between sex and prognostic impact of frailty/sarcopenia (P=0.806 for frailty; P=0.254 for sarcopenia). Conclusions Frailty and sarcopenia negatively affect older patients with heart failure from both sexes. Clinical trials This study was registered at the University Hospital Information Network (UMIN-CTR, unique identifier: UMIN000023929) before the first patient was enrolled.