Determination of brain death in children with 123I-IMP and Tc-99m HMPAO

We have introduced a new method for quantitative testing of cerebral perfusion and parenchymatous function. Tc-99m HMPAO and 123 I-IMP penetrate the intact blood-brain barrier, decay into secondary products, and are trapped inside the cells. Therefore, semiquantification of cellular uptake by static scintigraphic imaging allows easy evaluation of regional cerebral perfusion