Physalis peruviana oil based NLCs for dermal drug delivery

Nanostructured lipid carriers (NLC) are a new progression in the area of lipid nanoparticles which are preferred for topical use. NLC possess reasonable solubility enhancement capacity of poorly soluble drugs, which create a high concentration gradient to aid the permeation of drug. The endeavor of this study was to develop and analyze Physalis peruvianaoil based NLC. Theoilwas extracted by hot soxhlation using n-hexane as the solvent and the extracted oil wasutilized as an excipient (liquid lipid). Factorial design was adopted to optimize the amount of lipid blend (extracted oil and solid lipid), surfactant (Pluronic F-68) and sonication time to formulate NLC. The optimized formulations of fluconazole loaded NLC (PP-F-NLC) were evaluated by particle size, antifungal study, occlusion test, in-vitro skin permeation study and irritation test on animal skin. EE was found to be 99.96% and the optimized formulation showed 83% drug release in 24 hours. The formulated NLC showed better skin penetration, and potent antifungal activity against Microsporum fulvum as compared to marketed gel.It was concluded that the Physalis peruviana oil incorporated NLC is a promising formulation for fungal treatment and possesses high antioxidant potency.Physalis peruviana NLC can act as a potential carrier for anti-fungal/anti-inflammatory drugs to enhancethe purported pharmacological activity against various problems.