Puffy feet in a female neonate

A female neonate was evaluated due to limb oedema. Her father and three older siblings were healthy. Her mother had a subclinical autoimmune hypothyroidism. Gestation was uneventful, except for an abnormal maternal serum screening for aneuploidy during the first trimester. Amniocentesis revealed a normal female karyotype. A normal vaginal delivery occurred at 39 weeks. Physical examination showed bilateral dorsum foot oedema (figures 1 and 2). Cerebral ultrasound was normal and echocardiography revealed a patent foramen ovale. She was …