Intracranial electrographic analysis of preictal spiking and ictal onset in uni- and bitemporal epilepsy

Mesial temporal lobe epilepsy (mTLE) is a surgically amenable condition (Spencer, 2002), but presurgical non-invasive diagnostic evaluation may be insufficient to lateralize the condition and necessitate extraoperative electrocorticography (eECoG). This may, in turn, confirm bitemporal epileptogenicity in some cases(So et al., 1989a) despite a rather variable range of EEG features (Wasade et al., 2013). Preictal spiking (figure 1) identified by eECoG is specific to mesial temporal sclerosis (MTS) [...]