Maintaining the nelfinavir trough concentration above 0.8 mg/L improves virologic response in HIV-1-infected children.

Differences in virologic response were compared in 32 HIV-infected children with a nelfinavir trough concentration either below (n = 7) or above (n = 25) 0.8 mg/L. Virologic response at week 48 was observed in 29% of children with subtherapeutic nelfinavir troughs versus 80% in children with therapeutic nelfinavir troughs (P = .02).