Normative bladder diary measurements in pregnant women.

Abstract Objective Studies have demonstrated a strong positive correlation between bladder capacity and total volume voided in asymptomatic non-pregnant women. Therefore, to adequately characterise the normative data, it was important to compare bladder capacity vs. 24-h volume (V 24 ) relationships in our pregnant study population. Our objectives were to (1) collect normative bladder diary measurements from asymptomatic primigravid women, (2) investigate the relationship between these measurements and gestation of pregnancy, and (4) compare these normative measurements from pregnant women with those from asymptomatic non-pregnant women. We focused on measures of “bladder capacity” [average (“V avg ”) and maximum volume per void (“V max ”)], (“V 24 ”), and voiding frequency (“F 24 ”). Study design Three-day bladder diaries were collected from 41 primigravid women, one three-day diary per trimester. We compared our pregnant data with non-pregnant data previously collected by Amundsen et al. using identical methods. Relationship between variables analysed using the Kruskal-Wallace and Mann-Whitney tests. Results We found no significant differences across trimesters among bladder diary measurements (p-values: F 24  = 0.711; V max  = 0.912; V avg  = 0.894, and V 24  = 0.675). A comparison between pregnant and non-pregnant data showed no significant difference between F 24 , but a significantly lower V 24 , V avg and V max in pregnant women. Regression analysis showed no significant differences between the pregnant and non-pregnant, V 24 vs. bladder capacity relationships. Conclusions Pregnancy results in smaller bladder capacities and lower V 24 , with a normal relationship between V 24 and bladder capacity, maintaining normal voiding frequency. We used our data to construct a nomogram to help clinicians compare the relative contributions of increased V 24 and reduced bladder capacity to increased F 24 .