The comparative effect of capecitabine and tegafur/gimeracil/oteracil(S-1) on advanced colorectal cancer

2013 
Objective To test comparative effect of capecitabine and S-1 (Tegafur/gimeracil/oteracil) on advanced colorectal cancer.Methods 106 cases of advanced colorectal cancer in our hospital oncology were collected and randomly divided into 2 groups:capecitabine group (52 cases) and S-1 group (54 cases).The chemotherapy effect and adverse effect of 2 groups were collected.Results After one treatment period,3 cases of complete remission,19 cases of partial remission,15 cases of stable disease,15 cases of disease progression,efficient rate of 42.3%and control rate of 71.2% were observed in capecitabine group.5 cases of complete remission,21cases of partial remission,19 cases of stable disease,9 cases of disease progression and efficient rate of 48.1% and control rate of 83.3% were observed in S-1 group.There were no significant differences in efficient rate,control rate adverse effect rate and survival time between 2 groups(P > 0.05).Conclusion Capecitabine and S-1 are both safe and effective in treatment of advanced colorectal cancer. Key words: Colorectal neoplasms ;  Capecitabine ;  Gimeracil and Oteracil
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