Some aspects of left ventricular remodeling in patients With renal arterial hypertension (chronic renocardiac syndrome)

The attention of scientific community has been drawn to the Endophytes due to their capacity to produce novel bioactive compounds. In the present study, the bioprospecting of fungal endophytes from Ocimum sanctum L. was studied and were screened for their antimicrobial potential. Use of different parts of the plant led to isolation of eighteen endophytic fungi. Significant antimicrobial potential was shown by Nigrospora oryzae. isolated from the leaves of the plant under study. Antimicrobial potential was studied for the crude extracts of Nigrospora oryzae isolate with Hexane, Ethyl acetate and Methanol. The extract by ethyl acetate showed significant antimicrobial activity against E. coli, K. pneumonia, S. aureus. S. typhimurium, B. cereus and B. subtilis. The highest antimicrobial activity was shown against E. coli followed by K. pneumoniae and S. aureus. The study helped to justify the traditional use of Ocimum sanctum L. against human pathogenic bacteria. It also confirmed that the antimicrobial activity is attributable to the presence of endophytic fungi in the plant. It also leads to the justification that the studies on isolation and identification of the bioactive compounds can be an important and crucial approach to search for novel natural products.