Investigation of PAPP-A and Neopterin Levels in Behcet's Patients.

BACKGROUND: Behcet's disease (BD) is an autoimmune disease that affects many organs. We aimed to investigate the relationship between BD and these Pregnancy-associated plasma protein A (PAPP-A), neopterin and high sensitive C-reactive protein (hsCRP) parameters. MATERIALS AND METHODS: The study included 57 BD patients and 54 healthy controls. After evaluating the active and inactive disease status of the patients, analyzes were performed. RESULTS: When comparing the patient and control groups, neopterin (111.27 +/- 37.49; 76.77 +/- 38.27 (nmol/L) p <0.001) and hsCRP (11.81 +/- 16.8; 3.62 +/- 5.06 (mg/L); p = 0.001) parameters were significantly higher in patients. Neopterin (117.68 +/- 41.67; 94.85 +/- 14.75 neopterin; p= 0.038) and hsCRP (14.68 +/- 18.7; 4.47 +/- 7.27; p = 0.002) found different in active and inactive patients. The sensitivities of neopterin and hsCRP were also found to be high in BD (respectively 93%, 67%). PAPP-A was especially elevated in skin pathologies (p=0.02) and neopterin in joint involvement (p=0.03). CONCLUSIONS: We think that the use of neopterin and hsCRP can help in diagnosis and follow-up of BD. This article is protected by copyright. All rights reserved.