Anti-acetylcholinesterase, anti-α-glucosidase, anti-leishmanial and anti-fungal activities of chemical constituents of Beilschmiedia species

Abstract Phytochemical investigation of Beilschmiedia alloiophylla has resulted in the isolation of one new alkaloid, 2-hydroxy-9-methoxyaporphine ( 1 ), and ten known natural products, laurotetanine ( 2 ), liriodenine ( 3 ), boldine ( 4 ), secoboldine ( 5 ), isoboldine ( 6 ), asimilobine ( 7 ), oreobeiline ( 8 ), 6-epioreobeiline ( 9 ), β-amyrone ( 10 ), and ( S )-3-methoxynordomesticine ( 11 ). Chemical studies on the bark of B. kunstleri afforded compounds 2 and 4 along with one bisbenzylisoquinoline alkaloid, N -dimethylphyllocryptine ( 12 ). Structures of compounds 1 – 12 were elucidated on the basis of spectroscopic methods. All of these isolates were evaluated for their anti-acetylcholinesterase (AChE), anti-α-glucosidase, anti-leishmanial and anti-fungal activities. Compounds 1 – 12 exhibited strong to moderate bioactivities in aforementioned bioassays.