Programmed cell death protein-1 (PD-1)-expression in the microenvironment of classical Hodgkin lymphoma at relapse during anti-PD-1-treatment

Classical Hodgkin lymphoma (cHL) is characterized by rare Hodgkin and Reed Sternberg cells (HRSC), which are embedded in an anergic inflammatory cellular microenvironment (ME).[1][1] Constitutional and high expression of programmed cell death-protein-1 (PD-1)/PD-ligand (PD-L) pathway by HRSC