Inhibitory effects of a purified enterogasterone, secretin, and cholecystokinin on histamine-stimulated gastric acid secretion.

Inhibitory effects of a purified enterogastrone, highly purified secretin, cholecystokinin (Karolinska Institutet, Stockholm, Sweden), and Cecekin on gastric secretion stimulated with one-half the dose of histamine required for maximal stimulation were studied in dogs with Heidenhain’s pouches. The enterogastrone preparation (0.5- and 2.0-mg doses) inhibited gastric acid secretion, but secretin (75 clinical units) and cholecystokinin (Karolinska) (75 Ivy dog units) did not. The 0.5-mg dose of the inhibitor decreased gastric acid secretion 18% for 15 min. The 2.0-mg dose produced about 30%, decrease of gastric acid secretion for 30 min. Cecekin, a crude preparation of cholecystokinin, inhibited histamine-stimulated gastric secretion at a dose of 20 Ivy dog units.