Virulence in lymphomagenesis is modulated by alteractions in proteins binding to core and GRE-L Va elements of the MoMuL V enhancer

Changing nucleotide 3 of the CORE consensus from T to C has no effect on the binding of a 41 kDa protein, which has little affinity for the CCAAT binding site. Changing nucleotide 6 of the CORE consensus from T to C significantly reduces binding of the 41 kDa protein. Studies on the pathology induced by various MoMuLV mutants with CORE mutations showed that the CORE elements are important in modulating virulence in T-cell lymphomagenesis in BALB/c mice. However, disease specificity appears to be influenced as much by the host as it is by the virus