THE ROLE OF UNDIFFERENTIATED DYSPLASIA OF THE CONNECTIVE TISSUE IN THE DEVELOPMENT OF THE ENTEROCUTANEOUS FISTULA

Summary. Retro- and prospective trial was based on data about 30 patients, suffering entero-colocutaneous fistula, who were treated in the Shalimov National Institute of Surgery and Transplantology during 2016-2019.  There was revealed, that the most informative phenotypical markers of undifferentiated dysplasia of the connective tissue (UDCT) in patients, with entero-colocutaneous fistula, are visceral (83,3%), vascular (70%), arrhythmic (70%) syndromes. There was founded, that direct correlation between the level of biochemical markers of the collagen biodegradation and the UDCT degree may be applied for prognostication of development and course of complications in patients, suffering entero-colocutaneous fistula. Severe degree of UDCT in the patients, entero-colocutaneous fistula, constitutes unfavorable prognostic sign and enhances the mortality by 62.5%. The presence of UDCT in the patients winh entero-colocutaneous fistula is an aggravating comorbid factor that is difficult to be treated and accompanied by high rates of lethality, which must be taken into account, choosing the adequate surgical tactics and complex pathogenetically substantiated treatment.