Anticoagulation therapy after splenectomy in cirrhosis patient

Splenectomy for patients with cirrhosis has been well established. However, many issues in relation to postoperative management of these patients remain to be elucidated, mainly including reasons for portal vein thrombosis and anticoagulant use. In light of recent progresses on this topic, the current review summaries and pinpoints influencing factors of portal vein thrombosis, anticoagulant selection and corresponding rationales, monitor measures for anticoagulation, and treatment schemes for bleeding induced by anticoagulation. Our review focuses on issues associated with the selection and withdrawal time of anticoagulant. We conclude that patients undergoing splenectomy can benefit from postoperative anticoagulation, including enhanced postoperative recovery and decreasing incidence of postoperative complications. Key words: Liver cirrhosis; Splenectomy; Portal vein thrombosis; Anticoagulants