Effect of HMB on Phase Angle of Maintenance Hemodialysis Patients

Objective To observe and evaluate the effect of β- hydroxy-β- methylbutyric acid (HMB) on phase angle (PA) in maintenance hemodialysis (MHD) patients. Methods From March 2018 to August 2019, 64 patients who received maintenance hemodialysis, at Chengdu Fifth People's Hospital, were selected as subjects, and they were divided into experimental group and control group with single center, random, single dose, single blind control design, and 32 patients in each group. HMB intervention was performed in the trial group and placebo in the control group for 12 weeks. Human component analysis (Inbody S770) was performed before and after intervention in the two groups to observe the change of phase angle. Scored Patient-Generated Subjective Global Assessment (SGA) and Malnutrition Inflammatory Score (MIS) were used to assess the nutritional status of MHD patients before and after group entry, to observe the correlation of its numerical change and the phase angle. Results The PA, SGA, MIS of the experimental group was significantly higher (p<0.05) than that of the control group (p<0.05), and the test group increased better than the control group (p<0.05). Positive correlation between PA and SGA, MIS (p<0.05). Conclusions By giving patients complementary HMB, to improve patient nutritional status, to improve the patient phase angle, and improve the patient prognosis.