Systemic atrioventricular valve replacement in patients with functional single ventricle

Abstract Objective To review the outcome after atrioventricular valve replacement in single ventricle patients. Methods The medical records of 37 consecutive patients who underwent initial valve replacement between 2001 and 2016 were reviewed. Results Actuarial survival rates were 73%, 65%, and 59% at 1, 5, and 10 years, respectively. Multivariate analysis indicated body surface area 2 ( p  = 0.007; hazard ratio, 31.1), preoperative inotropic support ( p p  = 0.044; hazard ratio, 6.1), oversized prosthesis ( p  = 0.001; hazard ratio, 14.5), and intra- or postoperative extracorporeal membrane oxygenation support ( p 2 (interquartile range, 2.0-2.4) to 3.4 (2.8-3.7) ( p  = 0.002). Conclusions Atrioventricular valve replacement was a reasonable choice of treatment for single ventricle patients. For small patients with impaired ventricular function who had no choice other than valve replacement, commercially available valves were oversized and outcomes remained poor.