A case of peritoneal papillary serous adenocarcinoma successfully treated by intraperitoneal consecutive administration of cisplatin

The rare case of a 73-year-old woman with peritoneal papillary serous adenocarcinoma (PPSA), which was limited to the retroperitoneum, is described. She was admitted to our hospital because of vaginal bleeding and a pelvic mass. She had a total hysterectomy, double salpingo-oophorectomy, omentectomy, biopsy of the pelvic lymph nodes and subtotal tumorectomy. In immunohistochemical examinations, this tumor was diagnosed as PPSA, which was limited to the retroperitoneum without local or distant metastasis. Thereafter she received chemotherapy using a combination of cisplatin and cyclophosphamide at intervals of three weeks. Cisplatin was intraperitoneally administered in a divided dose of 20 mg from day 1 to day 4, and cyclophosphamide was intravenously infused in a dose of 500 mg on day 1. After three courses of this chemotherapy, a pathological complete response was observed and the only adverse effects were grade 1. In view of these advantages, this chemotherapy should be considered as first-line chemotherapy for aged patients with PPSA.