Hepatoid Adenocarcinoma of the Lung: A Case Report and Literature Review.

Hepatoid adenocarcinoma of the lung is a rare form of malignancy defined as an alpha-fetoprotein (AFP)-producing primary lung carcinoma with specific morphological features resembling hepatocellular carcinoma (HCC). Hepatoid lung adenocarcinomas are extremely rare. Due to the rarity of the tumor, any new case contributes to the clarification of its complete clinico-morphological description, biological behavior, and prognosis. It occurs in a multitude of organs: most frequently in the stomach, but also rarely in other areas, including the lung, kidney, female reproductive tract, pancreas, and gallbladder. We present a case of stage IV primary lung cancer with highly elevated AFP levels and morphological and immunohistochemical characteristics for hepatoid adenocarcinoma of the lung.