Metformin restores central nervous system remyelination capacity by rejuvenating aged stem cells

This work was supported by funding from the UK Multiple Sclerosis Society, MedImmune, The Adelson Medical Research Foundation and a core support grant from the Wellcome Trust and MRC to the Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute. We thank Dr Daniel Morrison for assistance with the electron microscopy, the NIHR Cambridge BRC Cell Phenotyping Hub for all flow cytometry work and staff at the Cambridge Advanced Imaging Centre.