Research progress in transient receptor potential cation channel subfamily A member 1 in the mechanism of neuropathic pain

Neuropathic pain (NP) is a direct pain caused by a lesion or disease of the somatosensory nervous system, which is the consequence of a complex interplay of mechanisms in the peripheral and central nervous systems and the most intractable pain syndrome. Transient receptor potential cation channel, subfamily A, member 1 (TRPA1) is involved in the formation of neuropathic pain and plays a crucial role in the integration of nociceptive signals. During NP, a large amount of oxidative stress products are released to cause hyperalgesia. TRPA1-specific antagonists are expected to be used in the treatment of neuropathic pain. This review summarizes the mechanism of TRPA1 activation and regulation and research progress in TRPA1 in NP, so as to provide new insights for pain management. Key words: Neuropathic pain; Transient receptor potential cation channel, subfamily A, member 1; Epigenetic regulation