Cardiac Sirt1 mediates the cardioprotective effect of caloric restriction by suppressing local complement system activation after ischemia-reperfusion

Sirt1 in cardiomyocytes is essential for the development of caloric restriction-induced cardioprotection and regulates expression levels of component 3 in cardiomyocytes. Thus we conclude that caloric restriction attenuates myocardial ischemia-reperfusion injury by suppressing local complement activation during ischemia-reperfusion in a Sirt1-dependent manner.