A Destroyer Immunologic Cause in Small Cell Lung Carcinoma: Ectopic Cushing's Syndrome

Ectopic secretion of adrenocorticotropic hormone (ACTH) related Cushinga#39;s syndrome (CS) is more frequently observed than many other paraneoplastic syndromes in patients with small cell lung cancer. Suppression of the cellular immune system in these patients is severe problem for both patients and physicians. In addition, the chemotherapy has been caused to severity and higher rate of hematological toxicity. We present a case of small cell lung cancer having a very poor prognosis, with a compressed humoral and cellular immune system due to an ectopic secretion of ACTH related CS. We report a rare case of combined immunosuppression in a case with small cell lung cancer in this paper. In addition, in the light of this special case and literature, we suggest treatment strategies for small cell lung cancer patients with CS. Ektopik adrenokortikotop (ACTH) salinmasina bagli Cushing sendromu, kucuk hucreli akciger kanserli hastalarda diger bircok paraneoplastik sendromlara gore daha sik gorulur. Bu hastalarda hucresel bagisiklik sisteminin baskilanmasi hem hekimler hem de hastalar icin onemli bir sorundur. Ek olarak kemoterapi, bu hastalarda siddetli ve daha yuksek oranda hematolojik toksisiteye neden olmaktadir. Biz ektopik ACTH salinmasi ile iliskili Cushing sendromuna bagli humoral ve hucresel bagisiklik sistemi baskilanmis cok kotu seyirli bir kucuk hucreli akciger vakasi sunduk. Ayrica, bu ozel vaka ve literatur isiginda Cushing sendrom olan kucuk hucreli akcigerli hastalar icin tedavi stratejileri onerdik.