Antimicrobial resistance of Enterococcus isolates in Turkey: A meta-analysis of current studies

Abstract Objectives In this study, a meta-analysis of Enterococcus isolates collected in 2000–2015 in Turkey and their susceptibility/resistance to antibiotics, clinical indications for initial drug treatment, and identification of alternative treatments was conducted. Methods The meta-analysis examined antibiotic susceptibility/resistance in Enterococcus spp. isolates. The study was planned and conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Statements on antimicrobial resistance were grouped according to the antimicrobial stewardship programme (ASP). Results The mean resistance rates of Enterococcus faecalis to vancomycin (VAN) and linezolid (LNZ) were 1.0 ± 2.2% and 1.9 ± 2.6%, respectively, whereas the mean resistance rates of Enterococcus faecium to VAN and LNZ were 10.3 ± 11.3% and 2.4 ± 0%, respectively. Conclusions This study is the first meta-analysis of the resistance of clinical Enterococcus isolates in Turkey to antimicrobial agents, which is a major problem stemming from the excessive usage of antibiotics. The development of antibiotic resistance in Turkey has changed over time. To support the practice of evidence-based medicine, more notifications about Enterococcus resistance status are needed, especially notifications following ASP rules.