Immuno-interception of Fertility: Current Status of Vaccines Developed Against hCG and LHRH

Three vaccines against hCG have undergone successfully Phase I clinical trial but only one HSD-hCG vaccine went through Phase II efficacy trials demonstrating its ability to prevent pregnancy without impairment of ovulation and derangement of menstrual cycles and bleeding profiles. A semisynthetic vaccine against LHRH has had Phase I/II clinical trials in India and Austria in 28 patients of carcinoma prostate. Highlights of these vaccines are presented. Issues related to clinical trials are discussed.