Beneficial modulation of the tumor microenvironment and generation of anti-tumor responses by TLR9 agonist lefitolimod alone and in combination with checkpoint inhibitors

Kerstin Kapp,Barbara Volz,Detlef Oswald,Burghardt Wittig,Matthias Baumann,Manuel Schmidt

Beneficial modulation of the tumor microenvironment and generation of anti-tumor responses by TLR9 agonist lefitolimod alone and in combination with checkpoint inhibitors

2019

Kerstin Kapp
Barbara Volz
Detlef Oswald
Burghardt Wittig
Matthias Baumann
Manuel Schmidt

ABSTRACTActivation of Toll-like receptor 9 (TLR9) is known to foster innate and adaptive immune responses and thus improve immune-mediated control of malignant disease. Lefitolimod is a potent TLR9...

Keywords:

Cancer research
Agonist
Tumor microenvironment
Medicine
TLR9
Receptor
Immunology
antitumor activity
Cancer immunotherapy
Immune system
immune checkpoint inhibitors

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