Prolonged complement activation in mice

Prolonged complement activation in mice. Because antibody responses to the alternative complement pathway activator, cobra venom factor, are T-dependent and B mice therefore do not develop resistance to its action, it was possible to examine whether renal injury occurs under circumstances of protracted third-phase alternative pathway activation. After periods of up to three months, no evidence from measurements of blood urea or proteinuria or from examinations with light microscopy immunofluorescence or electron microscopy was obtained to indicate a directly nephrotoxic effect of this type of complement activation. Activation prolongee du complement chez la souris. Du fait que les reponses a l'activateur de la voie alterne du complement, le venin de cobra, sont T-dependantes et puisque les souris B, de ce fait, ne developpent pas de resistance a son action, il a ete possible de rechercher la survenue de lesions renales au cours d'une activation prolongee de la voie alterne: Apres des delais atteignant jusqua'a trois mois, aucun argument de nephrotoxicite n'a ete tire des mesures d'uree sanguine et de proteinurie ou de l'etude en microscopie photonique, d'immunofluorescence et electronique.