Emissive Metallacycle-Crosslinked Supramolecular Networks with Tunable Crosslinking Densities for Bacterial Imaging and Killing.

: The chemical structures and topologies of the crosslinks in supramolecular networks play a crucial role in their properties and functions. Herein, we prepared a type of poly( N -isopropylacrylamide) (PNIPAAM)-based supramolecular networks crosslinked by emissive hexagonal metallacycles. The topological connections in these networks greatly affect their properties, as evidenced by their differences in absorption, emission, lower critical solution temperature, and modulus along with the variation of crosslinking densities. The integration of PNIPAAM and metallacycles in the networks benefits them improved bioavailability, making them serve as reagents for bacterial imaging and killing. This study provides a strategy to prepare cavity-crosslinked polymer networks for antibacterial applications.