Necrotizing pneumonia due to clonally diverse Staphylococcus aureus strains producing Panton-Valentine leukocidin: the Czech experience.
2016
A prospective study (2007–2013) was undertaken to investigate
clinical features and prognostic factors of necrotizing
pneumonia caused by Staphylococcus aureus producing
Panton–Valentine leukocidin (PVL) in the Czech Republic. Twelve
cases of necrotizing pneumonia were detected in 12 patients
(median age 25 years) without severe underlying disease. Eight
cases occurred in December and January and the accumulation of
cases in the winter months preceding the influenza season was
statistically significant (P < 0·001). The course of pneumonia
was very rapid, leading to early sepsis and/or septic shock in
all but one patient. Seven patients died and mortality was
fourfold higher in those patients presenting with primary
pneumonia than with pneumonia complicating other
staphylococcal/pyogenic infection elsewhere in the body. The S.
aureus isolates displayed considerable genetic variability and
were assigned to five lineages CC8 (n = 3), CC15 (n = 2), CC30
(n = 2), CC80 (n = 1), and CC121 (n = 3) and one was a
singleton of ST154 (n = 1), all were reported to be associated
with community-acquired infection. Four strains were
methicillin resistant. The high case-fatality rate can only be
reduced by improving the speed of diagnosis and a rapid test to
detect S. aureus in the airways is needed.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
41
References
8
Citations
NaN
KQI