Highly selective bisphosphine ligands for asymmetric hydroformylation of heterocyclic olefins

Abstract The bisphosphine ligand 1c is highly efficient and selective for the asymmetric hydroformylation (AHF) of dihydrofuran and pyrrolines. The AHF of 2,3-dihydrofuran yielded the 2-carbaldehyde in up to 93% ee. The remarkable highest regioselectivity of 2,5-dihydrofuran was obtained to date up to 499 β-isomer/α-isomer with ligand 1c . Furthermore, the highest 96% and 92% ee values were accomplished using the same catalytic system in the AHF of N -Boc pyrroline 11 and 14 .