Glucoprotein IIb/IIIa receptor antagonists,tirofiban induced acute thrombocytopenia in 1 patient

Forty-five -year-old woman with unstable angina pectoris received coronary arteriongraphy and percutaneous coronary intervention (PCI). The patient was treated with asprin 100 mg and clopidogrel 75 mg once daily from 14 days before PCI. Meanwhile low molecular heparin was injected subcutaneously for 7 days. GPⅡb/Ⅲa receptor antagonist tirofiban and heparin were given during PCI. Just 1 hour after PCI, the patient presented vaginal bleeding and then we found the platelet number decreased to 3×109L-1. All drugs mentioned above were stopped immediately. The patient was treated with gamma globulin and platelet infusion. After 4 days, the platelet counting recovered to normal level. We consider that the tirofiban maybe the initiated factor of acute thrombocytopenia.