Wound Healing Effects from 3 Hypericum spp. Essential Oils
2021
Hypericum species have a long-term use as wound healing agents, with the
most common preparation being the infused oil from the aerial parts. It contains
naphthodianthrones, phloroglucinols, and essential oil. An extensive literature
survey shows that, unlike napthodianthrones and phloroglucinols, essential oils
from Hypericum spp. have not yet been evaluated for their wound healing
efficacy. The present study aims to assess the wound healing efficacy of
essential oils from H. perforatum, a plant recognized in European
Pharmacopoeia for having wound healing properties, as well from 2 other
Hypericum species commonly used in Greece as wound healing agents
since classical antiquity, namely, H. empetrifolium and H.
triquetrifolium. So far, only the wound healing effects of Hypericum oil
are known, which is a different herbal preparation containing nonvolatile
compounds, while the essential oils under investigation contain only volatile
constituents. The essential oils were subjected to GC-MS analyses. Wounds were
created on the upper back of hairless SKH-hr1 mice. Healing was evaluated by
clinical, histopathological, and biophysical assessment. The essential oils
showed a significantly faster wound healing rate in comparison to the controls
and the vehicle-treated groups. H. empetrifolium possessed the most
significant healing properties while for H. perforatum and H.
triquetrifolium skin inflammation persisted. The essential oils from
Hypericum spp. showed promising results as wound healing agents and
are likely to contribute to the wound healing efficacy of the Hypericum
preparations. H. empetrifolium, being the most potent anti-inflammatory
and wound healing agent, confirms the traditional use of this plant in Greece
for wounds and skin inflammations.
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