Steroidkontrazeption und Hyperprolaktinämie

A study on the statistical correlation between (OCs) oral contraceptives and similar mixtures of steroids and the development and maintenance of hyperprolactinemia is presented. 91 cases with hyperprolactinemia-amenorrhea were compared to a group of 91 women with amenorrhea and normal prolactinemia. Matched pairs regarding duration of amenorrhea parity gonadal function and thyroid function were used. It was shown that OCs and similar combinations of estrogen and progesterone do not increase the relative risk for functional or adenomatous hyperprolactinemia. There was no evidence that existing adenomas were deteriorating during OC use. However 2 cases with pituitary adenoma following long-term high dosage estrogen therapy were found. The presented results show that low dosage steroid medications do not increase the risk for the development or maintenance of hyperprolactinemia. (authors modified) (summary in ENG)