Efficacy of Palonosetron for the Prevention of Postoperative Nausea and Vomiting: A Randomized, Double-Blinded, Placebo-Controlled Trial
2014
Abstract Background The aim of this study was to evaluate the efficacy of palonosetron, the latest 5-HT3 receptor antagonist, for the prevention of postoperative nausea and vomiting (PONV) during the first 72 h after operation. Methods In this randomized, double-blinded, placebo-controlled study, 204 healthy inpatients who were undergoing elective surgery with general anaesthesia were enrolled. Patients were divided into two groups: the palonosetron group (palonosetron 0.075 mg i.v.; n=102) and the placebo group (normal saline i.v.; n=102). The treatments were given after the induction of anaesthesia. The incidence of nausea, vomiting, severity of nausea, and the use of rescue anti-emetics during the first 72 h after surgery were evaluated. Results The incidence of PONV was lower in the palonosetron group compared with the placebo group during the 0–24 h (33% vs 47%) and 0–72 h period (33% vs 52%) (P Conclusions Palonosetron 0.075 mg i.v. effectively reduced the incidence of PONV during the first 72 h after operation, with most of the reduction occurring in the first 24 h.
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