Renin-angiotensin system of kidney and fetal originated glomerulosclerosis

It is well known that renin-angiotensin system of kidney (RAS) plays a crucial role in the development of glomerulosclerosis. Many previous studies have suggested that fetal renal dysplasia might increase susceptibility to renal diseases in adult offspring, which indicates that glomerulosclerosis has the fetal origin. Related studies have shown that adverse prenatal environment resulting from various factors can lead to pathological changes of RAS in fetal and adult period respectively, leading to dysplasia of fetal kidney development and the susceptibility to glomerulosclerosis in the adult offspring. Key words: Renin-angiotensin system (RAS) of kidney; Fetal originated glomerulosclerosis; Adverse prenatal environment