Improvement in Pulmonary Hypertension and Closure of a Patent Foramen Ovale with Treatment of Hyperthyroidism in a Patient with Graves’ Disease

Pulmonary hypertension and recurrence of a previously closed patent foramen ovale seen in Graves’ disease patients could be reversed with treatment of hyperthyroidism. We are reporting the case of a 41 year old woman, who presented with features of Graves’ disease and pulmonary hypertension which, in turn, led to a right to left shunt through a patent foramen ovale. After 8 weeks of treatment for hyperthyroidism, her pulmonary artery pressure decreased and patent foramen ovale was not noticeable. This is the first reported case of PFO closure with reduction of pulmonary artery pressure associated with treatment of hyperthyroidism to our knowledge.