Patient background related to success and adverse event in pediatric sedated MRI.

Background The success rate of sedation with triclofos sodium and midazolam for pediatric magnetic resonance imaging (MRI) has been reported. However, there are no reports of an association between adverse events and examination success rates and patient backgrounds using combinate these sedatives. We performed this study to investigate those points. Methods We investigated 191 pediatric patients who underwent sedative MRI with triclofos sodium and midazolam at Matsudo City Hospital between November 2013 and October 2015. We surveyed the characteristics of the patients' backgrounds, including age, sex, body weight, allergy, medication, neuromuscular disorders, gastrointestinal disorders, respiratory disorders, cardiac disorders, airway obstruction factors, and developmental disorders. Outcomes were sedation success and adverse events, including oxygen desaturation. We reviewed the relationship between patient backgrounds and each adverse event or success rate of sedation. Results Among all cases, the success rate was 92.7%. Older age (odds ratio [OR] = 0.984), developmental disorders (OR = 0.215), and respiratory disorders (OR = 0.353) were factors for lower success rates. Adding midazolam was associated with a higher success rate (OR = 5.971), but the higher total dose of midazolam was associated with sedation failure (OR = 0.003). The only adverse event was oxygen desaturation (11.5%). Older age affected oxygen desaturation with multiple analysis. However, by stepwise method, no patient backgrounds or sedative dose associated with oxygen desaturation. Conclusions Older age, developmental disorders, and respiratory disorders were associated with sedation failure. Increasing midazolam did not increase the success rate, and there might be an optimal dose of midazolam.