Abstract 12612: Exercise Training Reduces Ca2+-Calmodulin-dependent Protein Kinase Type II Dependent Phosphorylation of the Cardiac Ryanodine Receptor and Ca2+ Leak From the Sarcoplasmic Reticulum in Mice With Mutant Cardiac Ryanodine Receptor 2

Ravinea Manotheepan,Tore K. Danielsen,Mani Sadredini,Stephen Lehnart,Ivar Sjaastad,Mathis K. Stokke

Abstract 12612: Exercise Training Reduces Ca2+-Calmodulin-dependent Protein Kinase Type II Dependent Phosphorylation of the Cardiac Ryanodine Receptor and Ca2+ Leak From the Sarcoplasmic Reticulum in Mice With Mutant Cardiac Ryanodine Receptor 2

2013

Ravinea Manotheepan
Tore K. Danielsen
Mani Sadredini
Stephen Lehnart
Ivar Sjaastad
Mathis K. Stokke

Introduction: Catecholaminergic Polymorphic Ventricular Tachycardia caused by RyR2 mutations predisposes to stress-induced arrhythmias due to disrupted Ca2+ handling in ventricular cardiomyocytes. ...

Keywords:

Cell biology
Internal medicine
Cardiology
Ryanodine receptor
Calmodulin dependent protein kinase
Phosphorylation
Medicine
Mutant
Ryanodine receptor 2
Endoplasmic reticulum
gene mutation
Protein kinase A
Catecholaminergic polymorphic ventricular tachycardia

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