The prognosis of non‐small cell lung cancer combined with chronic obstructive pulmonary disease：a systematic review and meta‐analysis

OBJECTIVE: To investigate the effect of non-small cell lung cancer (NSCLC) combined with Chronic Obstructive Pulmonary Disease (COPD) on prognosis, so as to provide help to clinical diagnosis and treatment. METHODS: PubMed, Web of Science and the Medline were used to retrieve studies reported from 1950 to 2019. If the study reported the prognosis of COPD with NSCLC, the study was included and the relevant information was extracted and the data analyzed. The standard mean deviation (SMD) of 95% confidence interval was used in this meta-analysis. RESULTS: A total of 851 data studies were reviewed for eligibility, eventually, 12 case-control studies were included in this systematic review and meta-analysis. The sample sizes for company's studies of NSCLC ranged from 85 to 10 378, with a total number of 14 164, including 2450 COPD and 9395 Non-COPD. Meta-analyses showed that concomitant COPD was associated with poorer OS compared with patients without COPD (Fixed: HR: 1.16; 95% CI: 1.08-1.25. Random: HR: 1.07; CI: 0.92-1.24), with a significant heterogeneity across studies (I(2) = 45%, P = 0.04). CONCLUSION: Our study showed that patients with combined COPD had an impact on the prognosis and survival rate of SCLC patients.