L-asparaginase-induced pancreatic injury is associated with an imbalance in plasma amino acid levels.
2012
Background
The use of L-asparaginase (ASNase) to modify amino acid metabolism is one of the most effective chemotherapeutic means of inducing remission in acute lymphoblastic leukemia (ALL). However, severe pancreatitis sometimes occurs in patients receiving ASNase, because of an unknown mechanism.
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