A method for detecting specific autoantibodies rheumatoid polyarthritis.

Method of detecting autoantibodies (AAF) -specific rheumatoid polyarthritis (RP), in a biological sample likely to contain said autoantibodies (AAF) and other non-specific antibodies PR, whereby it provides, on one hand, one filaggrin (FNC) or a derivative of filaggrin (FNC) or a peptide of filaggrin (PFNC), said peptide after citrullination, an epitope of filaggrin, and secondly, said citrulline-containing filaggrin ( FC) or a derivative of said citrulline-containing filaggrin (FC) or said citrulline-containing peptide (PFC), consisting citrullination in the conversion of one or arginine residues to citrulline, said biological sample into contact sets with, for side, said filaggrin (FNC) or said derivative of said filaggrin (FNC) or said peptide (PFNC), and secondly, said citrulline-containing filaggrin (FC) or said derivative of said citrulline-containing filaggrin (FC) or said citrulline peptide ( PFC) In a condicionesapropiadas for immunocomplex formation with autoantibodies (AAF) is detected and the formation of immune complexes formed between the autoantibodies (AAF) or other antibodies present in the sample and said filaggrin (FNC) or said quantified derivative filaggrin (FNC) or said peptide (PFNC), on the one hand, and said citrulline-containing filaggrin (FC) or said derivative of said citrulline-containing filaggrin (FC) or said citrulline-containing peptide (PFC), on the other hand, being expressed this quantification for XNC and XC value respectively, the value of XC XNC to subtract.